Description :

Recent data from the phase iii rad001 in advanced neuroendocrine tumors fourth trial radiant 4 which contained a large population of patients with advanced well differentiated nonfunctional lung nets in addition to those with gi nets found a reduced risk of disease progression and death with everolimus compared with placebo leading to us approval of everolimus in these patient populations. Advances in pulmonary neuroendocrine tumor management by kjell oberg the spectrum of neuroendocrine tumors nets of the lung include on the one hand typical carcinoids and atypical carcinoids with a more indolent behavior and on the other hand the highly aggressive poorly differentiated large and small cell carcinomas. The who 2010 classification encompassed the previously named carcinoid tumors and defined a neuroendocrine tumor net as a well differentiated neuroendocrine neoplasm resembling the normal gut pancreas endocrine cells that expresses general markers of neuroendocrine differentiation chromogranin a and synaptophysin and hormones according to . Neuroendocrine neoplasms constitute a diverse group of tumors that derive from the sensory and secretory neuroendocrine cells and predominantly arise within the pulmonary and gastrointestinal tracts the majority of these neoplasms have a well differentiated grade and are termed neuroendocrine tumors nets